TS11A: INTRODUCTORY IMMUNOLOGY FOR CANCER AND AUTOIMMUNE DRUG DISCOVERY

TUESDAY, JUNE 18 - WEDNESDAY, JUNE 19

Skyline

INSTRUCTORS:

Tim Bauler, Ph.D., Assistant Professor, Department of Biomedical Sciences, Western Michigan University Homer Stryker M.D. School of Medicine

Thomas Sundberg, PhD, Group Leader, Cellular Pharmacology, Broad Institute of MIT and Harvard

This 1.5-day training seminar provides an introduction to human immunology. It focuses on how the immune system is organized and gives rise to both normal and pathogenic immune responses. We also discuss how the immune system can be modulated through biopharmaceutical intervention to either suppress pathogenic inflammation or enhance anti-tumor immunity for immuno-oncology therapeutics.

TOPICS TO BE DISCUSSED:

• Organization of the immune system
• Pathogen recognition by innate immune cells
• Antigen generation, capture, and presentation to lymphocytes
• Effector mechanisms of T cell responses
• Antibody generation and antibody-mediated cytotoxicity
• Molecular basis of pathogenic immune responses
• Protein-based immunomodulatory therapies
• Basic principles of immune-oncology (e.g., checkpoint blockade)
• Targeting immune processes with small molecules
• Role of host-microbe interactions in shaping the immune system

WHAT YOU WILL LEARN:

Rationale and mechanism of action behind many of the drug candidates in drug development for autoimmunity, inflammation and immuno-oncology.

WHO SHOULD ATTEND:

Discovery pharmacologists, biologists and chemists working in the biopharmaceutical industry or academics on inflammation, autoimmune, or immune-oncology programs.

INSTRUCTOR BIOGRAPHY:

Tim Bauler, Ph.D., Assistant Professor, Department of Biomedical Sciences, Western Michigan University Homer Stryker M.D. School of Medicine

Tim Bauler is a full-time medical educator who teaches immunology and infectious disease in an integrated curriculum combining basic science with clinical applications. Tim received a Ph.D. in Microbiology and Immunology from the University of Michigan after studying the role of protein tyrosine phosphatases in regulating proximal T cell signal transduction. His postdoctoral fellowship at Rocky Mountain Laboratories, NIAID, NIH, focused on the innate immune response to intracellular bacterial pathogens, including Salmonella Typhimurium and highly virulent Francisella tularensis which must be studied under Biosafety Level 3 containment.

Thomas Sundberg, PhD, Group Leader, Cellular Pharmacology, Broad Institute of MIT and Harvard

Tom Sundberg has expertise in chemical biology and translational immunology in the Center for Development of Therapeutics at the Broad Institute of MIT and Harvard. The focus of his work at CDoT is developing approaches to enhance anti-inflammatory functions of immune cells. As part of these efforts, he serves as a project lead for a collaboration with a biopharmaceutical industry partner developing first-in-class therapies for autoimmune/auto-inflammatory disorders. Tom received a Ph.D. in chemical biology from the University of Michigan at Ann Arbor and upon its completion in 2010 was awarded the American Cancer Society Postdoctoral Fellowship at Yale University; in the course of the fellowship, he studied new chemical biology approaches to targeted protein degradation.

DAY 1:

8:00 am - 4:00 pm Seminar Sessions

12:00 - 12:30 pm Lunch Provided

4:20 - 5:20 pm Plenary Keynote Session

5:20 - 6:35 pm Welcome Reception

6:35 - 7:30 pm Breakout Discussion Groups

DAY 2:

8:00 am - 12:00 pm Seminar Sessions

12:50 - 2:20 pm Plenary Keynote Session

Exhibit Hall Refreshment Breaks also provided.

Training Seminar Information

Each CHI Training Seminar offers 1.5 days of instruction with start and stop times for each day shown above and on the Event-at-a-Glance published in the onsite Program & Event Guide. Training Seminars will include morning and afternoon refreshment breaks, as applicable, and lunch will be provided to all registered attendees on the full day of the class.

Each person registered specifically for the Training Seminar will be provided with a hard copy handbook for the seminar in which they are registered. A limited number of additional handbooks will be available for other delegates who wish to attend the seminar, but after these have been distributed, no additional books will be available.

Though CHI encourages track hopping between conference programs, we ask that Training Seminars not be disturbed once they have begun. In the interest of maintaining the highest quality learning environment for Training Seminar attendees, and because seminars are conducted differently than conference programming, we ask that attendees commit to attending the entire program, and not engage in track hopping, as to not disturb the hands-on style instruction being offered to the other participants.